![]() /r/rigpics /r/buildapc /r/hardware /r/pcgaming /r/pcmasterrace /r/gamingpc /r/techsupport.Benchmarking & stress-testing Unigine Heaven 3D Markįull system information HWiNFO64 HWMonitor AIDA64 Speccy.Overclocking & monitoring MSI Afterburner CoreCtrl - for AMD on Linux.Stress-testing x264 Stress Test - for 99.9% stability on modern (Haswell and newer) Intel CPUs IntelBurnTest - extreme stress test similar to Prime95 Prime95 - for 100% stability on modern Intel, and all stability testing on AMD and older Intel CPUs Prime95 26.6 - for testing non-AVX speeds when using an AVX offset.Temperature monitoring CoreTemp RealTemp.Software overclocking & monitoring Intel XTU AMD Ryzen Master AMD OverDrive.CPU (AMD) AMD Ryzen Master Official Overclocking Guide (software) AMD FX Official Performance Tuning Guide AMD Guide (Bulldozer and Piledriver) AMD Dragon Platform (Phenom II) Official Performance Tuning Guide AMD Guide (Tom's Hardware) AM2/AM2+/AM3 Phenom/Phenom II Guide.9700K/9900K) Skylake Guide Haswell guide Ivy Bridge guide Sandy Bridge guide 1 CPU (Intel) Kaby Lake Guide - also applicable to Coffee Lake (inc.But feel free to message the mods about communities in other languages so we can link them in the sidebar. This also goes for abusing return policies as a way to bin. Warranties are for manufacturing defects, if you accidentally damage something that's on you. Do not advocate RMA fraud, or discuss attempting fraudulent RMAs.You're welcome to run them yourself, but respect the safe voltages listed in the wiki when answering questions. Do not tell people to run at unsafe settings.You can be happy about a good result without using such charged language. Check the full description in the wiki before making grand claims. Be sensible about what you claim as a "world record" or similar.Don't post unsubstantiated rumours, screenshots with context cropped out, or AMAs (unless preapproved by mods). Posts must contain enough information for a meaningful discussion, or to be meaningful content.In particular remember to use the report function rather than responding in anger, and that civil language does not excuse nasty comments. Follow sitewide Reddiquette and Self-Promotion Guidelines.More general hardware-related links, discussions and questions should be posted elsewhere, even if they happen to relate to a system that happens to be overclocked. This subreddit is for links, discussions and questions about overclocking (and underclocking).This is a short summary meant as a reminder - please read the full rules on the wiki before posting. ![]() ![]() r/overclocking wiki /r/overclocking IRC Join HWBOT to overclock competitively Rules You should always use your own judgement and realise that the only person responsible for any damage caused by overclocking is you. While posts may contain advice and suggestions to perform actions, you must understand that overclocking has all the potential to be a destructive process with irreversible results. This reddit may be used for providing and requesting help with overclocking processes.A place to share information, help those who are new to overclocking and brag about your latest sucessful overclock! IMPORTANT ![]()
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![]() ![]() To counteract CRISPR-mediated immunity, bacteriophages encode anti-CRISPR (Acr) proteins that neutralize the host CRISPR–Cas systems. In type I-E CRISPR–Cas systems, which is one of the most extensively studied subtypes, five Cas proteins (Cas5e, Cas6e, Cas7e, Cas8e, and Cas11) associate with crRNAs to form a CRISPR-associated complex for antiviral defense (Cascade) that recognizes target DNA sequences and directs their degradation by Cas3 nucleases. The type I CRISPR–Cas systems are broadly distributed in various prokaryotic genomes and can be divided into several subtypes depending on their signature Cas components. In class 1 (types I, III and IV) systems, multiple Cas proteins participate in the formation of the interference complex, whereas class 2 (types II, V and VI) systems use a single multi-domain Cas protein such as Cas9 or Cas12. Finally, the crRNAs assemble with Cas protein(s) to form RNA-guided interference complexes for degrading target sequences in re-invading foreign nucleic acids.ĬRISPR–Cas systems have been identified in ~ 40% of bacterial genomes and ~ 90% of archaeal genomes and can be classified into two major groups and six types. Then, the acquired DNA sequences are transcribed as a long precursor CRISPR RNA, which is further processed into mature CRISPR RNAs (crRNAs) containing a single spacer unit. First, Cas proteins form an integrase complex that cleaves and inserts the invading DNA fragments into CRISPR loci as new spacers. ![]() ĬRISPR-mediated immunity functions through three distinct stages of anti-phage defense. CRISPRs and Cas proteins constitute an RNA-based adaptive immune system against invading foreign genetic materials, such as bacteriophages and plasmids. Genes encoding CRISPR-associated (Cas) proteins lie adjacent to the CRISPR arrays. CRISPRs are a class of repetitive elements found in prokaryotic genomes that consist of invariable ‘repeat’ sequences interspaced with variable ‘spacer’ sequences. One such mechanism is clustered regularly interspaced short palindromic repeat (CRISPR)-mediated prokaryotic immunity against bacteriophages. Constant, intense viral infections have led to the development of numerous anti-phage defense systems in bacteria and archaea. These prokaryotic viruses are ubiquitous with their hosts in the ecosystem. Our findings corroborate and expand the knowledge on type I-E Acr proteins, illuminating diverse molecular mechanisms of inhibiting CRISPR-mediated prokaryotic anti-phage defense.īacteriophages, also known as phages, are viruses that infect bacteria and archaea. We also analyzed the interaction between AcrIE4 and its target Cas component using biochemical methods. Binding assays with type I-E Cas proteins were carried out for the target identification of AcrIE2. ![]() We determined the crystal structure of AcrIE2 using single-wavelength anomalous diffraction and performed a structural comparison with the previously reported AcrIE2 structures solved by different techniques. Here, we describe the biochemical characterization of two type I-E Acr proteins, AcrIE2 and AcrIE4. Several Acr proteins that act against type I-E CRISPR–Cas systems have been identified. The opposite goes for larger ions making the hydration energy of sodium be -406 KJ/mol and chloride to be -378 KJ/mol making the whole hydration energy of NaCl, -784 KJ/mol.In bacteria and archaea, CRISPRs and Cas proteins constitute an adaptive immune system against invading foreign genetic materials, such as bacteriophages and plasmids. The smaller the size of ions, the more will be the charge density and hence, more will be the hydration energy. The charge density is the amount of charge per unit volume of an ion. The concept of hydration energy rests entirely on charge density. ΔH latt = -787.3 KJ/mol Hydration energy of NaCl crystals The sodium and chloride ions in gaseous forms combine with each other to form a NaCl crystal lattice structure. The same happens in the case of NaCl lattice. Lattice energy is an estimation of bond energy in a compound which can be explained as the amount of energy released when gaseous opposite ions combine to make a lattice crystal. ![]() ![]() The game was earlier compatible with PC, PS, Xbox, and other consoles. GTA 5 APK is an open-world action-adventure game published by Coby. Rockstar Game Studio is the most well-known gaming studio in the gaming industry, which publishes many excellent games. Action game lovers must try it on Android mobile. You will also find a lot of weapons to fight here, which you must use. 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The first time you run a sketch in the emulator, Processing will ask you to download the system image needed by the emulator to work:Īfter finishing the download, which can take several minutes depending on your internet connection (the system images are around 1GB in size), Processing will boot up the emulator, and then will launch the sketch in it.Īnother important tip is not to close the emulator after testing one sketch, just leave it open so you don't need to wait for the emulator to boot up again the next time!ĭepending on what sketch you are testing, the emulator appear in a separate window, looking more or less like this: If you don't have a device to run your sketch on, you can still use the software emulator. If everything goes well, then your sketch should do something like this on your phone: If you downloaded the Android SDK automatically in Processing, then the latest USB drivers will be inside the mode folder, under the temp subfolder. If you are running Windows, you need to follow Google's documentation to install a special USB driver and take care of additional settings. ![]() On Android 4.2 and higher the Developer Options are hidden by default, but you can enable them by following these instructions. In most of the cases, this setting is located in the Developer Options, under system Setting. Turn on "USB Debugging" on the device - this process varies by device and which version of the OS you have installed.Rect( width/2, 0, width/2, height) // Rightīefore hitting the run button or selecting "Run on Device" under the Sketch menu, make sure to: This portability of Processing sketches (as long as they don't rely on any platform-specific features) is useful for testing, as the Java mode includes an integrated debugger that can help to spot errors in the code more easily. ![]() Note that nothing in this sketch is really specific to Android, so you could run it in the Java mode as well. In the following code, we paint the half of the screen receiving a touchpress with the color black. Let's write a short Processing sketch to run on your Android phone or tablet and make sure everything works as expected. If the SDK was located or installed succesfully, you should see your Android device in the "Select device" list after connecting it to the computer: However, keep in mind that the SDK that Processing downloads and installs automatically gets stored inside the mode folder, and does not interfere with any other SDK installed in your computer. Doing this could be convenient if you plan to use the same SDK from different development tools (command line, Android Studio, etc.) in addition to Processing. In order to manually download and install the SDK, go to this page, scroll down to the command line tools section and select the one for your Operating System. ![]() However, this SDK should include Android 8.0 (API level 26) or higher. 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This skinny margarita recipe is right out of my Mexican vacation (that seems so very long ago). When I order a margarita in Mexico, I get a drink with tequila and lime over ice. A skinny margarita has fewer calories and less sugar than a traditional margarita. I really hate to be a snob but those frozen margaritas are not the authentic drink. ![]() All you have to do is avoid the huge cup of margarita from a slushie machine. ![]() ![]() ![]() 6/27: Let’s Go Gayming – STORY OF SEASONS: A Wonderful Life.Keep an eye out for LIVEs from DIGIPRIDE on TikTok: During Pride Month and 30 Days of #GamingonTikTok, we're thrilled to be partnering with to amplify #Gayming on TikTok with special Pride-themed LIVEs, creator spotlights, and more. 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